![]() ![]() ![]() Rag2 −/− mice showed impaired learning/memory performance in the Morris water maze (MWM) task, but this impairment was not attributable to B cell deficiency as B cell-deficient mouse (μMT mice) performance was comparable to controls. ![]() Interestingly, mice with a T cell receptor against endogenous myelin basic protein (MBP) showed enhanced hippocampal neurogenesis and improved spatial learning in comparison to mice with a T cell receptor to non-self antigen ( 8). Neurogenesis impairment was found to be dependent on CD4 + lymphocytes, as transplantation of CD8 + lymphocytes into Rag2 −/− mice (lacking T and B cells) did not rescue the effect in the same manner ( 9). Hippocampal neurogenesis is dependent on the adaptive immune system, and is significantly impaired in severe combined immune deficiency (SCID) mice that lack T and B lymphocytes due to a Rag1/2 gene deletion ( 8). T cells in Brain Development and BEHAVIOR ![]()
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